THE HIGH AFFINITY PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND DAA1106 BINDS TO ACTIVATED AND INFECTED BRAIN MACROPHAGES IN AREAS OF SYNAPTIC DEGENERATION: IMPLICATIONS FOR PET IMAGING OF NEUROINFLAMMATION IN LENTIVIRAL ENCEPHALITIS

HIV encephalitis (HIVE) is characterized by neurodegeneration mediated by toxins derived from infected and activated brain macrophages.Since the peripheral benzodiazepine receptor (PBR) is abundant on brain macrophages, we hypothesized that [3H]DAA1106, a Whisky Glasses new PBR ligand, can label infected and activated brain macrophages in HIVE.Usin

Background: Prolificacy has a high economic value and is one of the most important reproduction traits in small ruminants such as Markhoz goats, which is an endangered breed.Objective: To estimate genetic, environmental and phenotypic trends, and genetic parameters for litter size (LS), as a prolificacy trait of Markhoz goat does.Methods: The study

The efficacy of integrating open access geospatial data to produce habitat suitability maps for the corn bunting (Miliaria calandra) was investigated.Landsat Enhanced Thematic Mapper Plus (ETM+), Shuttle Radar Topography Mission (SRTM) and Corine (Coordination of Information on the Environment) land cover data for the year 2000 (CLC2000) were proce

New additional conditions required for the uniqueness of the 2D elastostatic problems formulated in terms of potential functions for the derived Papkovich-Neuber representations, are studied.Two cases are considered, each of them formulated by the scalar potential function plus Foot Cream one of the rectangular non-zero components of the vector pot

Background: Infectious diseases escalation in developing countries especially in Indonesia lead to increasing use of antibiotics in the community.Self-medication with antibiotics may increase the risk of resistant bacteria and irrational use of Shoes antibiotics.This study was conducted to determine the relationship between socioeconomic -demograph